日本性感染症学会誌 Journal of Japanese Society for Sexually Transmitted Infections

We analyzed the Mycoplasma genitalium (MG) positivity rate and clinical characteristics in 304 patients presenting with symptoms of urethritis who visited our clinic from January to December 2023. The MG positivity rate was 20.1% (61/304 cases). Among MG-positive patients, the rate of follow-up visits for post-treatment confirmation was 49.2% (30/61 cases); of these patients, MG eradication was confirmed in only 56.7% (17/30 cases). Coinfection with Neisseria gonorrhoeae and/or Chlamydia trachomatis was observed in 18.0% of the MG-positive cases. However, patients who initially underwent only NG/CT PCR testing and subsequently added TV/MG PCR demonstrated significantly lower detection rate of coinfections than those who simultaneously received both tests at the initial visit. These findings suggest that appropriate screening at the initial consultation, including testing for MG, is crucial for preventing missed diagnoses of MG and its coinfections. Furthermore, the development of standardized treatment guidelines for MG is warranted.