日本性感染症学会誌 Journal of Japanese Society for Sexually Transmitted Infections

A 51-year-old man presented to our hospital with discomfort in the penis. He was infected with human immunodeficiency virus (HIV) and was receiving antiretroviral therapy. Physical examination revealed a mass on the glans penis; however, the serum squamous cell carcinoma antigen level was low. Kaposi’s sarcoma of the penis was initially suspected, and a biopsy of the glans tumor was performed, which confirmed a diagnosis of penile squamous cell carcinoma. The patient subsequently underwent partial penectomy, and pathological examination confirmed grade 3 squamous cell carcinoma. Consequently, inguinal lymph node dissection was also performed.

At 8 months postoperatively, the patient remained free of recurrence or metastasis. In HIV-infected patients with penile neoplasm, differential diagnosis should include both Kaposi’s sarcoma and human papillomavirus-induced penile cancer.