日本性感染症学会誌 Journal of Japanese Society for Sexually Transmitted Infections

Mycoplasma genitalium (MG) infection has been associated with various gynecological diseases, including cervicitis and pelvic inflammatory disease. In this study, we investigated the infection rate and the efficacy of antimicrobial agents in 902 patients who underwent MG testing at our hospital. The infection rates were 27.9% and 18.5% in females and males, respectively, indicating a relatively high positivity rate, which may be attributed to the high proportion of commercial sex workers among our patients. Regarding treatment, many patients had previously received macrolide antibiotics for chlamydia infections; therefore, doxycycline was selected as the first-line monotherapy for MG, with quinolone antibiotics as the second-line treatment. The results revealed that doxycycline had a 58.5% efficacy rate, whereas that of the other antibiotics was approximately 60%, indicating a high prevalence of multidrug-resistant MG infections. Subsequently, a two-drug sequential antibiotic therapy (doxycycline+quinolone antibiotics) administered according to the CDC guidelines, achieved a 90% efficacy rate, supporting the effectiveness of sequential therapy for multidrug-resistant MG infection.