日本性感染症学会誌 Journal of Japanese Society for Sexually Transmitted Infections

Online ISSN: 2434-2505 Print ISSN: 0917-0324
日本性感染症学会 Japanese Society for Sexually Transmitted Infections
〒162-0801東京都新宿区山吹町358-5アカデミーセンター Japanese Society for Sexually Transmitted Infections Academy Center, 358-5 Yamabuki-cho, Shinju-ku, Tokyo 162-0801, Japan
Japanese Journal of Sexually Transmitted Infections 29(1): 127-131 (2018)
doi:10.24775/jjsti.29.1.127

症例報告症例報告

ポドフィリン外用が奏効した小児の尖圭コンジローマの2例Successful treatment of condyloma acuminatum with topical podophyllin: A report on two cases

東京慈恵会医科大学皮膚科学講座Department of Dermatology, The Jikei University School of Medicine

受付日:2018年4月7日Received: April 7, 2018
受理日:2018年8月16日Accepted: August 16, 2018
発行日:2018年9月30日Published: September 30, 2018
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In children, condyloma acuminatum is relatively rare, and the pain associated with the surgical treatment may be intolerable for them. Since the efficacy and safety of topical imiquimod remain unknown, its pediatric use is presently prohibited. Therefore, we used topical podophyllin to treat condyloma acuminatum in two children. Two girls aged 22 and 23 months were referred to our clinic with a diagnosis of condyloma acuminatum. A 20% ethanol solution was created, using podophyllin from Sigma-Aldrich, and applied to the papules twice a week. The lesions gradually regressed and the pain and inflammation became minimal. Finally, after four and nine months, respectively, both cases healed completely without subsequent recurrence. In Japan, imiquimod is the only topical drug used to treat condyloma acuminatum. However, children do not have access to it through the Japanese health insurance system. After familial consent, we used podophyllin combined with a reagent and achieved good results. Although there are no data presently available on the safety of podophyllin in children, it is considered as one of the first choices for the treatment of condyloma acuminatum in children. In other countries condyloma acuminatum is treated with podophylox, which is considered to be safer than podophyllin. Introduction of podophylox is required in Japan.

Key words: condyloma acuminatum; children; podophyllin

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